The indigenous inhabitant is predominantly Ovambos/Aawambo who speak three language of the Oshiwambo Languages – Oshikwanyama, Oshindonga and Otshikwambi.

Insignificant number of other Namibian tribes and ethnic groups live in the region.  In 2001, Oshana Region had a population of 161 916, with a population density of about 18.8 per square kilometers and a growth rate of 3 percent per annum.

Sixty-nine percentum (69%) of the population lives in the rural areas, whereas thirty-one percentum (41%) lives in the urban areas.  Oshakati, the capital and largest town, had inhabitants.

The official language is English.  Afrikaans, Portuguese and other African languages are sparsely spoken here and there.